Symbol
Name
ID

Il21
interleukin 21
MGI:1890474

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Decreased circulating IgG level	Hemolytic anemia	Decreased proportion of class-switched memory B cells	Abnormal T cell count	Leukopenia	Thrombocytopenia
Disease(s) Associated with IL21	Increased circulating IgE level	Decreased circulating IgG level	Hemolytic anemia	Decreased proportion of class-switched memory B cells	Abnormal T cell count	Leukopenia	Thrombocytopenia
common variable immunodeficiency 11
systemic lupus erythematosus

Mouse Phenotypes

abnormal class switch recombination

abnormal T cell differentiation

decreased germinal center B cell number

decreased CD4-positive, alpha-beta T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal gamma-delta T cell morphology

abnormal spleen germinal center morphology

decreased spleen germinal center number

abnormal germinal center B cell physiology

increased IgE level

decreased IgG1 level

abnormal CD4-positive, alpha-beta T cell physiology

Availability

Mouse Genotype

Il21^tm1Lex/Il21^tm1Lex

Il21^tm1Llit/Il21^tm1Llit

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23